Gene Therapy for Hypercholesterolemia

Gene therapy for hypercholesterolemia: sweet dreams and flying machines.

Adenovirus gene therapy for hypercholesterolemia, thrombosis and restenosis.

Human adenoviruses are non-enveloped, icosahedral viruses, approximately 130 nm in diameter. The linear, double-stranded DNA viral genome containing covalently attached terminal protein derived from a unique replication process is almost 36 Kb in length. Although forty nine serotypes of human adenovirus in six serological subgroups have been identified, only serotypes 2 and 5 of subgroup C have...

Probiotics as complementary therapy for hypercholesterolemia

The role of probiotic organisms as alternative or complementary therapy in combating large number of gastro intestinal disorders and their ability to enhance immune response attracts global attention. In addition, their therapeutic use towards cholesterol-lowering activities has further increased their applications as effective probiotics for humans as supplements in milk and yoghurt, since the...

ژن درمانی Gene Therapy

Garlic extract therapy in children with hypercholesterolemia.

OBJECTIVE To determine whether garlic extract therapy is efficacious and safe in children with hypercholesterolemia. DESIGN Randomized, double-blind, placebo-controlled clinical trial. SETTING Specialized pediatric lipid disorders ambulatory clinic. PARTICIPANTS Thirty pediatric patients, aged 8 to 18 years, who had familial hyperlipidemia and a minimum fasting total cholesterol level gre...